Publications
Patterns of Brain Maturation in Autism and Their Molecular Associations
Pretzsch CM, Arenella M, Lerch JP, Lombardo MV, Beckmann C, Schaefer T, Leyhausen J, Gurr C, Bletsch A, Berg LM, Seelemeyer H, Floris DL, Oakley B, Loth E, Bourgeron T, Charman T, Buitelaar J, McAlonan G, Murphy D, Ecker C; EU-AIMS LEAP Group.
Agomelatine in pediatric patients with moderate to severe major depressive disorder: an open-label extension study
Arango C, Fegert JM, Picarel-Blanchot F, Marx U, Truffaut-Chalet L, Pénélaud PF, Buitelaar J
Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents
Kurth F, Schijven D, van den Heuvel OA, Hoogman M, van Rooij D, Stein DJ, Buitelaar JK, Bölte S, Auzias G, Kushki A, Venkatasubramanian G, Rubia K, Bollmann S, Isaksson J, Jaspers-Fayer F, Marsh R, Batistuzzo MC, Arnold PD, Bressan RA, Stewart SE, Gruner P, Sorensen L, Pan PM, Silk TJ, Gur RC, Cubillo AI, Haavik J, O’Gorman Tuura RL, Hartman CA, Calvo R, McGrath J, Calderoni S, Jackowski A, Chantiluke KC, Satterthwaite TD, Busatto GF, Nigg JT, Gur RE, Retico A, Tosetti M, Gallagher L, Szeszko PR, Neufeld J, Ortiz AE, Ghisleni C, Lazaro L, Hoekstra PJ, Anagnostou E, Hoekstra L, Simpson B, Plessen JK, Deruelle C, Soreni N, James A, Narayanaswamy J, Reddy JY, Fitzgerald J, Bellgrove MA, Salum GA, Janssen J, Muratori F, Vila M, Giral MG, Ameis SH, Bosco P, Remnélius KL, Huyser C, Pariente JC, Jalbrzikowski M, Rosa PG, O’Hearn KM, Ehrlich S, Mollon J, Zugman A, Christakou A, Arango C, Fisher SE, Kong X, Franke B, Medland SE, Thomopoulos SI, Jahanshad N, Glahn DC, Thompson PM, Francks C, Luders E.
The breakdown of social looking
Falck-Ytter T.
Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency
Delling JP, Bauer HF, Gerlach-Arbeiter S, Schön M, Jacob C, Wagner J, Pedro MT, Knöll B, Boeckers TM.
Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
Riemersma IW, Ike KGO, Sollie T, Meijer EL, Havekes R, Kas MJH.
Tracing the paths: a systematic review of mediators of complex trauma and complex post-traumatic stress disorder
Harris J, Loth E, Sethna V.
Autistic and nonautistic adolescents do not differ in adaptation to gaze direction
Ward EK, Buitelaar JK, Hunnius S.
Structural models of genome-wide covariance identify multiple common dimensions in autism
de Hoyos L, Barendse MT, Schlag F, van Donkelaar MMJ, Verhoef E, Shapland CY, Klassmann A, Buitelaar J, Verhulst B, Fisher SE, Rai D, St Pourcain B.
Attention-deficit/hyperactivity disorder
Faraone SV, Bellgrove MA, Brikell I, Cortese S, Hartman CA, Hollis C, Newcorn JH, Philipsen A, Polanczyk GV, Rubia K, Sibley MH, Buitelaar JK.
Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort
Mei T, Llera A, Forde NJ, van Rooij D, Floris DL, Beckmann CF, Buitelaar JK.
Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium
Ioannidis V, Pandey R, Bauer HF, Schön M, Bockmann J, Boeckers TM, Lutz AK.
Expression profiles of the autism-related SHANK proteins in the human brain
Woelfle S, Pedro MT, Wagner J, Schön M, Boeckers TM.
Infant responses to direct gaze and associations to autism: A live eye-tracking study
Rudling M, Nyström P, Bussu G, Bölte S, Falck-Ytter T.
Shank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue
Yildiz B, Schiedt L, Mulaw M, Bockmann J, Jesse S, Lutz AK, Boeckers TM.
The sensory-first account of autism
Falck-Ytter T, Bussu G.
How 18-month-olds with Later Autism Look at Other Children Interacting: The Timing of Gaze Allocation
Viktorsson C, Bölte S, Falck-Ytter T.
A stable and replicable neural signature of lifespan adversity in the adult brain
Holz NE, Zabihi M, Kia SM, Monninger M, Aggensteiner PM, Siehl S, Floris DL, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Orfanos DP, Paus T, Poustka L, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Meyer-Lindenberg A, Brandeis D, Buitelaar JK, Nees F, Beckmann C; IMAGEN Consortium; Banaschewski T, Marquand AF.
Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits
Isakoglou C, Haak KV, Wolfers T, Floris DL, Llera A, Oldehinkel M, Forde NJ, Oakley BFM, Tillmann J, Holt RJ, Moessnang C, Loth E, Bourgeron T, Baron-Cohen S, Charman T, Banaschewski T, Murphy DGM, Buitelaar JK, Marquand AF, Beckmann CF.
Pre-pragmatic language use in toddlerhood: Developmental antecedents, aetiological factors, and associations to autism
Rudling M, Portugal AM, Bölte S, Falck-Ytter T.
A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders
Lombardi L, Le Clerc S, Wu CL, Bouassida J, Boukouaci W, Sugusabesan S, Richard JR, Lajnef M, Tison M, Le Corvoisier P, Barau C, Banaschewski T, Holt R, Durston S, Persico AM, Oakley B, Loth E, Buitelaar J, Murphy D, Leboyer M, Zagury JF, Tamouza R.
Phenotypic effects of genetic variants associated with autism
Rolland T, Cliquet F, Anney RJL, Moreau C, Traut N, Mathieu A, Huguet G, Duan J, Warrier V, Portalier S, Dry L, Leblond CS, Douard E, Amsellem F, Malesys S, Maruani A, Toro R, Børglum AD, Grove J, Baron-Cohen S, Packer A, Chung WK, Jacquemont S, Delorme R, Bourgeron T.
The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
Cortese S, McGinn K, Højlund M, Apter A, Arango C, Baeza I, Banaschewski T, Buitelaar J, Castro-Fornieles J, Coghill D, Cohen D, Grünblatt E, Hoekstra PJ, James A, Jeppesen P, Nagy P, Pagsberg AK, Parellada M, Persico AM, Purper-Ouakil D, Roessner V, Santosh P, Simonoff E, Stevanovic D, Stringaris A, Vitiello B, Walitza S, Weizman A, Wohlfarth T, Wong ICK, Zalsman G, Zuddas A, Moreno C, Solmi M, Correll CU.
Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism
Pretzsch CM, Floris DL, Schäfer T, Bletsch A, Gurr C, Lombardo MV, Chatham CH, Tillmann J, Charman T, Arenella M, Jones E, Ambrosino S, Bourgeron T, Dumas G, Cliquet F, Leblond CS, Loth E, Oakley B, Buitelaar JK, Baron-Cohen S, Beckmann CF, Persico AM, Banaschewski T, Durston S, Freitag CM; EU-AIMS/AIMS-2-TRIALS Consortium; Murphy DGM, Ecker C.
Global motion processing in infants’ visual cortex and the emergence of autism
Hardiansyah I, Nyström P, Taylor MJ, Bölte S, Ronald A, Falck-Ytter T.
Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism
Ilioska I, Oldehinkel M, Llera A, Chopra S, Looden T, Chauvin R, Van Rooij D, Floris DL, Tillmann J, Moessnang C, Banaschewski T, Holt RJ, Loth E, Charman T, Murphy DGM, Ecker C, Mennes M, Beckmann CF, Fornito A, Buitelaar JK.
Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment
Loth E
Dissecting the 22q13 region to explore the genetic and phenotypic diversity of patients with Phelan-McDermid syndrome
Vitrac A, Leblond CS, Rolland T, Cliquet F, Mathieu A, Maruani A, Delorme R, Schön M, Grabrucker AM, van Ravenswaaij-Arts C, Phelan K, Tabet AC, Bourgeron T.
Downregulation of the Autism Spectrum Disorder Gene Shank2 Decreases Bone Mass in Male Mice
hmad M, Stirmlinger N, Jan I, Stifel U, Lee S, Weingandt M, Kelp U, Bockmann J, Ignatius A, Böckers TM, Tuckermann J.
Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders
Bauer HF, Delling JP, Bockmann J, Boeckers TM, Schön M
Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice
Atanasova E, Arévalo AP, Graf I, Zhang R, Bockmann J, Lutz AK, Boeckers TM
Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project
Looden T, Floris DL, Llera A, Chauvin RJ, Charman T, Banaschewski T, Murphy D, Marquand AF, Buitelaar JK, Beckmann CF; AIMS-2-TRIALS group
Social COmmunication Program supported by E-health (SCOPE) for infants and toddlers at elevated likelihood of autism spectrum disorder: study design of a cluster randomized controlled trial
Snijder MIJ, Dietz C, van Andel M, Ruiter ELM, Buitelaar JK, Oosterling IJ
The Link Between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression
Floris DL, Peng H, Warrier V, Lombardo MV, Pretzsch CM, Moreau C, Tsompanidis A, Gong W, Mennes M, Llera A, van Rooij D, Oldehinkel M, Forde NJ, Charman T, Tillmann J, Banaschewski T, Moessnang C, Durston S, Holt RJ, Ecker C, Dell’Acqua F, Loth E, Bourgeron T, Murphy DGM, Marquand AF, Lai MC, Buitelaar JK, Baron-Cohen S, Beckmann CF; APEX Group; EU-AIMS LEAP Group.
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
Hettwer MD, Larivière S, Park BY, van den Heuvel OA, Schmaal L, Andreassen OA, Ching CRK, Hoogman M, Buitelaar J, van Rooij D, Veltman DJ, Stein DJ, Franke B, van Erp TGM; ENIGMA ADHD Working Group; ENIGMA Autism Working Group; ENIGMA Bipolar Disorder Working Group; ENIGMA Major Depression Working Group; ENIGMA OCD Working Group; ENIGMA Schizophrenia Working Group, Jahanshad N, Thompson PM, Thomopoulos SI, Bethlehem RAI, Bernhardt BC, Eickhoff SB, Valk SL.
From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans
Ahmad J, Ellis C, Leech R, Voytek B, Garces P, Jones E, Buitelaar J, Loth E, Dos Santos FP, Amil AF, Verschure PFMJ, Murphy D, McAlonan G.
What are you looking at? Gaze following with and without target objects in ASD and typical development
Thorup E, Nyström P, Bölte S, Falck-Ytter T.
Cerebellar Atypicalities in Autism?
Laidi C, Floris DL, Tillmann J, Elandaloussi Y, Zabihi M, Charman T, Wolfers T, Durston S, Moessnang C, Dell’Acqua F, Ecker C, Loth E, Murphy D, Baron-Cohen S, Buitelaar JK, Marquand AF, Beckmann CF, Frouin V, Leboyer M, Duchesnay E, Coupé P, Houenou J; EU-AIMS LEAP Group.
Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders
Garrido D, Beretta S, Grabrucker S, Bauer HF, Bayer D, Sala C, Verpelli C, Roselli F, Bockmann J, Proepper C, Catanese A, Boeckers TM
Autism is associated with inter-individual variations of gray and white matter morphology
Mei T, Forde NJ, Floris DL, Dell’Acqua F, Stones R, Ilioska I, Durston S, Moessnang C, Banaschewski T, Holt RJ, Baron-Cohen S, Rausch A, Loth E, Oakley B, Charman T, Ecker C, Murphy DGM; EU-AIMS LEAP group, Beckmann CF, Llera A, Buitelaar JK.
Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology
Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Nov;8(11):1084-1093. doi: 10.1016/j.bpsc.2022.08.011. Epub 2022 Sep 6.ABSTRACTBACKGROUND: Although many studies have explored atypicalities in gray matter (GM) and white matter (WM) morphology of autism, most of them...
Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project
Llera A, Brammer M, Oakley B, Tillmann J, Zabihi M, Amelink JS, Mei T, Charman T, Ecker C, Dell’Acqua F, Banaschewski T, Moessnang C, Baron-Cohen S, Holt R, Durston S, Murphy D, Loth E, Buitelaar JK, Floris DL, Beckmann CF
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Hansen JY, Shafiei G, Vogel JW, Smart K, Bearden CE, Hoogman M, Franke B, van Rooij D, Buitelaar J, McDonald CR, Sisodiya SM, Schmaal L, Veltman DJ, van den Heuvel OA, Stein DJ, van Erp TGM, Ching CRK, Andreassen OA, Hajek T, Opel N, Modinos G, Aleman A, van der Werf Y, Jahanshad N, Thomopoulos SI, Thompson PM, Carson RE, Dagher A, Misic B.
Low-grade inflammation as mediator between diet and behavioral disinhibition: A UK Biobank study
Shi H, Schweren LJS, Ter Horst R, Bloemendaal M, van Rooij D, Arias Vasquez A, Hartman CA, Buitelaar JK.
Parental Experiences with Early Identification and Initial Care for their Child with Autism: Tailored Improvement Strategies
Snijder MIJ, Langerak IPC, Kaijadoe SPT, Buruma ME, Verschuur R, Dietz C, Buitelaar JK, Oosterling IJ.
Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review
Tamouza R, Volt F, Richard JR, Wu CL, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E.
Qualitative differences in the spatiotemporal brain states supporting configural face processing emerge in adolescence in autism
Haartsen R, Mason L, Garces P, Gui A, Charman T, Tillmann J, Johnson MH, Buitelaar JK, Loth E, Murphy D, Jones EJH; EU-AIMS LEAP group.
SHANK3 Antibody Validation: Differential Performance in Western Blotting, Immunocyto- and Immunohistochemistry
Lutz AK, Bauer HF, Ioannidis V, Schön M, Boeckers TM
SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system
Malara M, Lutz AK, Incearap B, Bauer HF, Cursano S, Volbracht K, Lerner JJ, Pandey R, Delling JP, Ioannidis V, Arévalo AP, von Bernhardi JE, Schön M, Bockmann J, Dimou L, Boeckers TM
Deletion of the Autism-Associated Protein SHANK3 Abolishes Structural Synaptic Plasticity after Brain Trauma
Urrutia-Ruiz C, Rombach D, Cursano S, Gerlach-Arbeiter S, Schoen M, Bockmann J, Demestre M, Boeckers TM
Age-related brain deviations and aggression
Holz NE, Floris DL, Llera A, Aggensteiner PM, Kia SM, Wolfers T, Baumeister S, Böttinger B, Glennon JC, Hoekstra PJ, Dietrich A, Saam MC, Schulze UME, Lythgoe DJ, Williams SCR, Santosh P, Rosa-Justicia M, Bargallo N, Castro-Fornieles J, Arango C, Penzol MJ, Walitza S, Meyer-Lindenberg A, Zwiers M, Franke B, Buitelaar J, Naaijen J, Brandeis D, Beckmann C, Banaschewski T, Marquand AF
The gut microbiome as mediator between diet and its impact on immune function
Shi H, Ter Horst R, Nielen S, Bloemendaal M, Jaeger M, Joosten I, Koenen H, Joosten LAB, Schweren LJS, Vasquez AA, Netea MG, Buitelaar J.
Neurobiological Correlates of Change in Adaptive Behavior in Autism
Pretzsch CM, Schäfer T, Lombardo MV, Warrier V, Mann C, Bletsch A, Chatham CH, Floris DL, Tillmann J, Yousaf A, Jones E, Charman T, Ambrosino S, Bourgeron T, Dumas G, Loth E, Oakley B, Buitelaar JK, Cliquet F, Leblond CS, Baron-Cohen S, Beckmann CF, Banaschewski T, Durston S, Freitag CM; EU-AIMS LEAP Group, Murphy DGM, Ecker C.
Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder
Riemersma IW, Havekes R, Kas MJH
SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(-/-) Mice
Lutz AK, Pérez Arévalo A, Ioannidis V, Stirmlinger N, Demestre M, Delorme R, Bourgeron T, Boeckers TM.
Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
Delling JP, Boeckers TM.
Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis
Rudling M, Nyström P, Bölte S, Falck-Ytter T.
Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms
Szopinska-Tokov J, Dam S, Naaijen J, Konstanti P, Rommelse N, Belzer C, Buitelaar J, Franke B, Aarts E, Arias Vasquez A.